of klotho-deficient mice that have a shortened lifespan and demonstrate age-related phenotypes such as atherosclerosis,osteoporosis,and emphysema .The human klotho gene has more than 80% homology with the mouse gene ,and polymorphisms in the human klotho gene are anticipated to influence the age-related diseases.Association of KLOTHO gene polymorphisms with knee The Journal of Orthopaedic Research,a publication of the Orthopaedic Research Society (ORS),is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research,including life sciences,engineering,translational,and clinical studies.Author Atma Gunawan,Jonny Karunia Fajar,Fredo Tamara,Aditya Indra Mahendra,Muhammad Ilmawan,Yeni PurnaPublish Year 2020Association of Klotho and interleukin 6 gene polymorphisms Certain gene polymorphisms are associated with human aging.This study investigated polymorphisms of a metabolism-related gene,Klotho,and an inflammatory gene,IL6,for association with the aging process in a healthy Han Chinese population.A total of 482 healthy subjects were recruited and divided into aging and young groups according to chronological age and biological age.
Author Rosa Maria R Pereira,Thiago Quadrante Freitas,André Silva Franco,Liliam Takayama,Valeria F CaparPublish Year 2020KLOTHO polymorphisms and age-related outcomes in
May 22,2020·Defective KLOTHO gene expression in mice led to a syndrome resembling human ageing.This study evaluated three KLOTHO polymorphisms,namely G395A,C1818T,and C370S,in an elderly population (meanAuthor Rosa Maria R Pereira,Thiago Quadrante Freitas,André Silva Franco,Liliam Takayama,Valeria F CaparPublish Year 2020KLOTHO polymorphisms and age-related outcomes inThere is only one publication regarding KLOTHO polymorphisms and age-related comorbidities in a Brazilian population10.Hence,the present study seeks to evaluate three KLOTHO gene polymorphisms in anCited by 110Publish Year 2006Author Eun-Jung Rhee,Ki-Won Oh,Won-Young Lee,Se-Yeon Kim,Chan-Hee Jung,Byung-Jin Kim,Ki-Chul Sung,Bu(PDF) KLOTHO polymorphisms and age-related outcomes in PDF Defective KLOTHO gene expression in mice led to a syndrome resembling human ageing.This study evaluated three KLOTHO polymorphisms,namely G395A,Find,read and cite all the research
Cited by 19Publish Year 2018Author Agnieszka Olejnik,Aleksandra Franczak,Anna Krzywonos-Zawadzka,Marta Kauna-Oleksy,Iwona Bil-LulNitride oxide synthase 3 and klotho gene F1000Research
Apr 09,2020·Furthermore,investigating the role of NOS and klotho gene polymorphisms in the case of age-related cognitive impairment and CKD was logical and crucial for better understanding concerning the development of aging and CKD.Cited by 20Publish Year 2008Author Aspasia Tsezou,Tatsuya Furuichi,Maria Satra,Periklis Makrythanasis,Shiro Ikegawa,Konstantinos NAssessment of Matrix Gla Protein,Klotho Gene ity of Klotho.26 KL-VS allele is related with high risk of atherosclerosis in individuals with untimely CVD.27 In this study,we investigated the association between MGP and Klotho gene polymorphisms and CKD.The aim of this study was to dene the distribution of MGP Glu60X,Thr83Ala,T-138C,and Klotho Cys370SerCited by 29Publish Year 2013Author Tracey B.Tucker Zhou,Gwendalyn D.King,CiDi Chen,Carmela R.AbrahamKlotho gene polymorphisms are associated with healthy Jan 10,2019·KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects The São Paulo Ageing Health (SPAH) Study.Pereira RMR,Freitas TQ,Franco AS,Takayama L,Caparbo VF,Domiciano DS,Machado LG,Figueiredo CP,Menezes PR,Onuchic LF,de Castro I.Sci Rep,10(1):8574,22 May 2020
Cited by 2Publish Year 2014Author W.G.Zhang,X.J.Bai,D.P.Chen,Y.Lv,X.F.Sun,G.Y.Cai,X.Y.Bai,Xiang-Mei ChenKlotho gene polymorphisms are related to colorectal cancer
Found in 1997,Klotho gene is related to aging process [9,10] and starts to attract peoples attention on its influence on tumors in recent years [11,12].Multiple researches successively reported the relevance of Klotho gene to tumors like breast cancer,lung cancer,pancreatic cancer and colon cancer [12-15].Cited by 4Publish Year 2018Author Qiukui Hao,Yuting Wang,Xiang Ding,Biao Dong,Ming Yang,Birong Dong,Yuquan WeiAssociation of Klotho and interleukin 6 gene polymorphisms Jun 05,2014·Certain gene polymorphisms are associated with human aging.This study investigated polymorphisms of a metabolism-related gene,Klotho,and an inflammatory gene,IL6,for association with the aging process in a healthy Han Chinese population.Cited by 4Publish Year 2019Author Zewu Zhu,Weiping Xia,Yu Cui,Feng Zeng,Yang Li,Zhongqing Yang,Chen HequnAssociation of Klotho gene polymorphism with hypertension ·Extensive studies have unveiled Klothos anti-aging effects as well as differential impacts of age on the association of Klotho polymorphism with CAD [ 20,27 ].Accordingly,we divided the participants into two subgroups,namely,younger and older than 57years,on the basis of the median for the age of all the subjects [ 20 ].
Cited by 5Publish Year 2018Author Hamed Akbari,Gholamreza Asadikaram,Hamid Aria,Saba Fooladi,Sina Vakili,Mohammad MasoumiKlotho Gene Polymorphisms Associated With Bone Density
Because mice deficient in klotho gene expression exhibit multiple aging phenotypes including osteopenia,we explored the possibility that the klotho gene may contribute to agerelated bone loss in humans by examining the association between klotho gene polymorphisms and bone density in two genetically distinct racial populations the white and the Japanese.Screening of singlenucleotide Cited by 7Publish Year 2015Author Chang Liu,Wei Cui,Li Wang,Lei Yan,Xinjian Ruan,Yanfang Liu,Xiaoyan Jia,Xia ZhangBiochemical and Functional Characterization of the Klotho Background The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown.Results In vitro,klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c.Conclusion Altered dimerization explains klotho-VS association with increased disease risk.Significance Understanding how the VS variantIt has been proposed that polymorphisms within the KL (klotho) gene have a significant effecton aging,in particular,the osteoblast defect of aging.The association between polymorphisms within this gene and biochemical markers of bone formation and resorption,bone structure,and fracture rates was studied in 1,190 postmenopausal women with a mean age of 75 years.Klotho Gene Polymorphisms are Associated with Osteocalcin Was this helpful?KLOTHO polymorphisms and age-related outcomes inDefective KLOTHO gene expression in mice led to a syndrome resembling human ageing.This study evaluated three KLOTHO polymorphisms,namely G395A,C1818T,and C370S,in an elderly population (mean age of 73 years) and their associations with ageing-related outcomes (cardiovascular events,kidney function,osteoporosis,sarcopenia) and mortality.
Sep 11,2006·The entire coding region of the klotho gene will be sequenced looking for functional variants and polymorphisms that differentiate two groups of adult dialyzed ESRD patients,matched for age and gender,and with comparable values for dialysis dose and daily protein intake.Klotho a link between cardiovascular and non Klotho genetic polymorphisms may influence these clinical relationships and predict cardiovascular risk; rs9536314 was the polymorphism most frequently involved in these associations.These findings suggest that Klotho and its genetic polymorphisms may represent a bridge between inflammation,salt sensitivity,hypertension and mortality.Klotho gene polymorphisms are associated with healthy ·A total of 632 participants (68.4% females; mean age 93.5±3.2 years) were included.KL G-395A polymorphism genotype frequencies were 1.7%
Some results are removed in response to a notice of local law requirement.For more information,please see here.12345NextThe Biological Role of Klotho Protein in the Development
Klotho is a membrane-bound or soluble antiaging protein,whose protective activity is essential for a proper function of many organs.In 1997,an accidental insertion of a transgene led to creation of transgenic mice with several age-related disorders.In Klotho-deficient mice,the inherited phenotypes closely resemble human aging,while in an animal model of Klotho overexpression,the The differential effects of age on the association of Differential effects of age were observed in the association of KLOTHO G-395A and C1818T polymorphisms with CAD in Koreans.The KL-VS variant seems to be rarely found in the Korean population.These results infer the possibility of the KLOTHO gene being a candidate gene of atherosclerosis in humans,and further research on this topic needs to be done.